Effect of mupirocin in Helicobacter pylori in vitro

Mupirocin (MUP) is an effective antibiotic against MRSA. Its bactericidal effect stable under acid condition. By validating its antibacterial of Helicobacter pylori, we try to clarify MUP on H. pylori. The present study was conducted investigate the clarithromycin (CLR) / metronidazole (MNZ) -resistant and -susceptible strains time-kill MUP, post (PAE). We investigated minimal inhibitory concentration (MIC) (MBC) 140 which include clinical strains, ATCC43504, 26695 J99. Ten them were CLR 3 MNZ-resistant strains. MIC90 MBC all 0.064 μg ml, 0.1 respectively. There no differences between susceptible resistant either for or MNZ. Time-kill curve test PAE ATCC43504 performed. adding showed that bacterial quantities decreased in dose time-dependent manner. No viable colony found after 12-hour culture with ml MUP. value 12. a potential pylori even those MNZ